There is an abundance of quality fixtures across this weekend with the Six Nations and Super Rugby leading the way.
Scotland are hoping to make history at Twickenham as Italy aspire to get off the mark, while Wales and Ireland could serve up a classic on Friday night.
Not forgetting the Blues-Highlanders derby on Saturday among six Super Rugby fixtures.
Let's see who will come out on top.
Preview: Currently three points behind Eddie Jones’ side with two games to play, Ireland know a loss could see England seal the title on Saturday.
Prediction: It could well be a cracker in Cardiff and one which Wales may just come up short against powerful visitors. Ireland by six.
Preview: Italy head into this clash on a ten-match losing streak in the tournament with their last victory registered just over two years ago when they beat Scotland.
Prediction: Although Italy will put up a brave fight, the visitors have too much class. France to win by 12 points!
Preview: England will hope to make it a record-equalling 18 Test victories in Tier 1 rugby when they take on Scotland.
Prediction: A lot depends on Owen Farrell's fitness but if he starts then the hosts should make it four from four. England by three.
Prediction: This should be a tough clash between two side’s who will be eager to bounce back from disappointing losses from the week before and catch their New Zealand competitors early in the point table. But the home-ground advantage should see the Blues through. Blues by 5.
Prediction: The Reds will struggle against this dangerous Crusaders side if they keep their momentum from last week. Expect a blowout in Brisbane. Crusaders by 15.
Prediction: The Kings are looking like a far better side than last year but shouldn't be any trouble for the away side. Stormers by 17.
Prediction: Although the end result will not be as big a scoreline as their previous meeting, the home side should win this one comfortably again. Cheetahs to win by 35 points.
Prediction: Despite an early-season tour and travel on their plate, the hosts should relish being back in Durban this week. Sharks by ten.
Prediction: Much the same is expected as last year when a weakened Lions XV turned up at Velez Sarsfield. Jaguares by 10.
Bordeaux-Bègles v Grenoble: UBB by 9
Lyon v Stade Français: Lyon by 5
Toulon v Bayonne: Toulon by 15
Brive v Toulouse: Toulouse by 3
Racing 92 v La Rochelle: La Rochelle by 7
Pau v Castres: Pau by 3
Clermont Auvergne v Montpellier: Clermont by 6
Ulster v Zebre: Ulster by 25