David Pocock and Israel Folau will return to action for the Wallabies in the Rugby World Cup semi-final against Argentina.
Pocock and Folau have been declared fully fit for the clash after Friday's training session and will take their place in the starting XV, along with prop James Slipper who replaces the injured Scott Sio (elbow).
Slipper, who captained the side against the USA in Chicago last month, will start at loosehead prop while Toby Smith comes on to the reserves bench as the Wallabies prepare for their sixth Rugby World Cup semi-final appearance.
Vice-captain Michael Hooper will have the honour of making his 50th Test appearance in the final four clash as the Wallabies battle for a place in the Rugby World Cup Final.
Drew Mitchell will once again line up on the wing, needing just one more try to draw level with Bryan Habana and Jonah Lomu as the all-time Rugby World Cup leading try scorer.
With the return of Pocock and Folau, quarter-final starters Ben McCalman and Kurtley Beale revert to the bench.
Wallabies coach Michael Cheika said: “James has been pushing for a starting spot with his performances as a finisher and I know he’ll take it with both hands.
“James is a leader in our squad and has performed well through this tournament so far and in the lead-up matches.
“This weekend is a great opportunity for the lads to improve on last week and take advantage of the chance to play on such a big stage.
“This weekend we want to make Australia proud of their team.”
Australia: 15 Israel Folau, 14 Adam Ashley-Cooper, 13 Tevita Kuridrani, 12 Matt Giteau, 11 Drew Mitchell, 10 Bernard Foley, 9 Will Genia, 8 David Pocock, 7 Michael Hooper, 6 Scott Fardy, 5 Rob Simmons, 4 Kane Douglas, 3 Sekope Kepu, 2 Stephen Moore (c), 1 James Slipper
Replacements: 16 Tatafu Polota-Nau, 17 Toby Smith, 18 Greg Holmes, 19 Dean Mumm, 20 Ben McCalman, 21 Nick Phipps, 22 Matt Toomua, 23 Kurtley Beale
Date: Sunday, October 25
Venue: Twickenham Stadium, London
Kick-off: 16:00 GMT
Referee: Wayne Barnes (England)
Assistant Referees: Jaco Peyper (South Africa), George Clancy (Ireland)
TMO: Ben Skeen (New Zealand)