Bristol have suffered a major setback with fly-half Tusi Pisi being ruled out for up to 12 weeks after sustaining a groin injury.
The Samoan international back picked up the injury during the first-half of the Premiership match against Newcastle Falcons on October 8.
15 members of the Bristol squad are unavailable for selection through injury.
"Adrian Jarvis is unavailable with a calf injury, joining Gavin Henson (dead leg) in the treatment room," read a medical update on Monday.
"Callum Sheedy (hamstring) is expected to be sidelined for another six weeks, while Academy centre Nick Carpenter could miss up to twelve weeks following surgery on a shoulder injury.
"Martin Roberts (elbow) is set to miss a further ten weeks, while Ben Mosses (knee), Max Crumpton (knee) and Jamal Ford-Robinson (shoulder) are unavailable for selection.
"Front-row trio Marc Jones (knee), Ryan Bevington (knee) and Alec Clarey (back) are ruled out, and locks Glen Townson (knee), Joe Joyce (foot) and Sam Jeffries (heel) are also among the injured squad members."