The Cheetahs have named their side that will face the Lions at Ellis Park on Saturday, with Joe Pietersen moving into the full-back shirt.
Naka Drotské's side enters the derby without injured duo Willie le Roux and Heinrich Brüssow, with Tienie Burger replacing the latter at openside.
Meanwhile, loosehead prop BG Uys is suffering from a back injury and has been ruled out for three weeks. He will be replaced by Danie Mienie with Caylib Oosthuizen named on the bench as cover.
In the backline, Willie du Plessis will direct the team from fly-half alongside scrum-half Sarel Pretorius, with Clayton Blommetjies on the bench.
The last game between these two teams was on April 5, 2014 at the Free State Stadium in Bloemfontein, which ended in a 43-43 scoreline.
Cheetahs: 15 Joe Pietersen, 14 Cornal Hendricks, 13 Johann Sadie, 12 Francois Venter, 11 Ryno Benjamin, 10 Willie du Plessis, 9 Sarel Pretorius, 8 Willie Britz, 7 Boom Prinsloo, 6 Tienie Burger, 5 Francois Uys (c), 4 Carl Wegner, 3 Coenie Oosthuizen, 2 Torsten van Jaarsveld, 1 Danie Mienie.
Replacements: 16 Stephan Coetzee, 17 Caylib Oosthuizen, 18 Maks van Dyk, 19 Steven Sykes, 20 Carel Greeff, 21 Tian Meyer, 22 Michael van der Spuy, 23 Clayton Blommetjies.
Date: Saturday, April 25
Venue: Ellis Park, Johannesburg
Kick-off: 17:05 (15:05 GMT, 01:05 AEST, 03:05 NZST)
Referee: Jaco van Heerden
Assistant referees: Marius van der Westhuizen, Ben Crouse
TMO: Johan Greeff