Sergio Parisse is back to make his first appearance for Italy in the World Cup in their crucial clash with Ireland.
The Azzurri need to win at the Olympic Stadium to keep their quarter-final hopes alive, and will be pleased to get Parisse back after he missed the first two games with a leg injury.
He replaces Samuela Vunisa at number eight, with Simone Favaro also getting the nod in the back row.
Up front Leonardo Ghiraldini is absent, so Andrea Manici comes into the starting lineup, and Matias Aguero is preferred to Michele Rizzo at loosehead.
The other change comes in the centres where Michele Campagnaro replaces Tommaso Benvenuti from the team that battled past Canada last time out.
There is also no spot for Martin Castrogiovanni in the matchday squad, with Lorenzo Cittadini starting at tighthead, and Dario Chistolini on the bench.
Italy: 15 Luke McLean, 14 Leonardo Sarto, 13 Michele Campagnaro, 12 Gonzalo Garcia, 11 Giovanbattista Venditti, 10 Tommaso Allan, 9 Edoardo Gori, 8 Sergio Parisse (c), 7 Simone Favaro, 6 Francesco Minto, 5 Josh Furno, 4 Quintin Geldenhuys, 3 Lorenzo Cittadini, 2 Andrea Manici, 1 Matias Aguero.
Replacements: 16 Davide Giazzon, 17 Michele Rizzo, 18 Dario Chistolini, 19 Alessandro Zanni, 20 Mauro Bergamasco, 21 Guglielmo Palazzani, 22 Carlo Canna, 23 Tommaso Benvenuti.
Date: Sunday, October 4
Venue: Olympic Stadium, London
Kick-off: 16:45 local
Referee: Jérôme Garcès (France)
Assistant Referees: Pascal Gauzère (France), Angus Gardner (Australia)
TMO: Graham Hughes (England)