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Munster won the right to face Biarritz in the Heineken Cup semi-finals courtesy of a tense 33-19 win over Northampton Saints on Saturday.
Eight missed kicks cost Clermont a place in the Heineken Cup semi-finals on Friday in a 29-28 defeat to defending champions Leinster.
Five weeks ago these two teams met at Stade de France in what should have been one of the Top 14's benchmark games.
It will be D-Day at Estadio Anoeta this Saturday as the Ospreys travel to face Biarritz for their make-or-break Heineken Cup battle in Spain.
It's the quarter-finals opener, a clash that many believe ought to be the Final, a clash from which many believe the champions will come.
Toulouse will play their Heineken Cup quarter-final at home after they clinched a workmanlike 19-13 win over Sale Sharks.
Biarritz booked a home Heineken Cup quarter-final by coming from behind to beat Glasgow 41-20 in France on Sunday.
Cardiff Blues head to the Amlin Challenge Cup after recording an emphatic 45-20 victory over Harlequins at the Stoop on Sunday
London Irish's assault on the Heineken Cup finally ran out of steam on Saturday with an 11-11 draw with Leinster at Twickenham.
Gloucester claimed a spot in the Amlin Challenge Cup by recording a 32-23 win over the Dragons at Rodney Parade on Sunday.
The Scarlets recovered from a ten-point deficit to earn themselves a 20-17 victory over Brive at Stade Municipal on Saturday.
Edinburgh finished their 2009/10 Heineken Cup campaign on a high with the scalp of Stade FranÃ§ais in a 9-7 victory at Murrayfield.
Ulster's last-ditch quest for a Heineken Cup quarter-final place ended in failure despite a 28-10 win in Bath on Saturday.
The Ospreys have, barring miracles, battled their way into another Heineken Cup quarter-final with a 17-12 win over Leicester in Swansea.
Clermont secured a home Heineken Cup quarter-final on Saturday after running nine tries past Viadana in a 59-20 rampage in Italy.
Jordan Turner-Hall returns to the Harlequins starting line-up to face Cardiff Blues in the Heineken Cup at the Stoop on Sunday.
The Perpignan tight five scored four of their team's five tries as the Catalans rumbled to a 34-6 home win over Treviso on Friday.
Stade FranÃ§ais have left France centre Mathieu Bastareaud on the bench for their decisive Heineken Cup clash with Edinburgh on Saturday.
Wales back James Hook has been handed a big opportunity from inside centre against Leicester at Liberty Stadium on Saturday.
Wings Topsy Ojo and Sailosi Tagicakibau return to action for London Irish in Saturday's Heineken Cup match with Leinster at Twickenham.