Sean O'Brien will captain Ireland against Scotland on Saturday while Jack Conan makes his international debut in Dublin.
O'Brien becomes the 103rd man to lead his country as he assumes the captain's armband for Saturday's encounter against the Scots.
The Tullow man is joined in the back-row by Chris Henry and Conan who is set to win his first senior cap.
Devin Toner and Dan Tuohy lock down in the second-row while Mike Ross is joined by Sean Cronin and Dave Kilcoyne in the front-row.
Isaac Boss and Ian Madigan pair up in the half-backs with Gordon D'Arcy and Jared Payne teaming up in the centres.
The back three sees Simon Zebo at full-back with Tommy Bowe and Luke Fitzgerald on the wings.
The replacements are Richard Strauss, Michael Bent, Nathan White who could earn his first cap off the bench, Paul O'Connell, Jordi Murphy, Eoin Reddan, Paddy Jackson and Dave Kearney.
Ireland: 15 Simon Zebo, 14 Tommy Bowe, 13 Jared Payne, 12 Gordon D'Arcy, 11 Luke Fitzgerald, 10 Ian Madigan, 9 Isaac Boss, 8 Sean O'Brien (c), 7 Chris Henry, 6 Jack Conan, 5 Dan Tuohy, 4 Devin Toner, 3 Mike Ross, 2 Sean Cronin, 1 Dave Kilcoyne.
Replacements: 16 Richardt Strauss, 17 Michael Bent, 18 Nathan White, 19 Paul O'Connell, 20 Jordi Murphy, 21 Eoin Reddan, 22 Paddy Jackson, 23 Dave Kearney.
Date: Saturday, August 15
Venue: Aviva Stadium, Dublin
Kick-off: 17:00 local (16:00 GMT)
Referee: Pascal Gauzère (France)
Assistant Referees: Jérôme Garcès (France), Marius Mitrea (Italy)
TMO: Graham Hughes (England)