Chiefs head coach Dave Rennie has rung the changes for Saturday's Super Rugby clash in Buenos Aires against the Jaguares.
Hika Elliot and Hiroshi Yamashita come into the front row to join Mitchell Graham, with Michael Allardice and Johan Bardoul making up the rest of the tight five.
Tom Sanders returns to the back row as he joins co-captain Sam Cane and Japan number eight Michael Leitch.
Three changes in the backline see Tawera Kerr-Barlow start at scrum-half with Sam McNicol coming in on the wing. Anton Lienert-Brown also takes over from Seta Tamanivalu at outside centre for his first start of the season.
Chiefs head coach Dave Rennie said: “The Jaguares are an impressive unit but we’ve prepared well, and are looking forward to the challenge.
"We’ve been well looked after since our arrival and it’s exciting to be part of the first Super Rugby game in Argentina. We’ll have to feed off the passionate and vocal crowd.”
Chiefs: 15 Damian McKenzie, 14 Sam McNicol, 13 Anton Lienert-Brown, 12 Charlie Ngatai, 11 James Lowe, 10 Aaron Cruden (cc), 9 Tawera Kerr-Barlow, 8 Michael Leitch, 7 Sam Cane (cc), 6 Tom Sanders, 5 Johan Bardoul, 4 Michael Allardice, 3 Hiroshi Yamashita, 2 Hika Elliot, 1 Mitchell Graham
Replacements: 16 Rhys Marshall, 17 Pauliasi Manu, 18 Siate Tokolahi, 19 Taleni Seu, 20 Maama Vaipulu, 21 Brad Weber, 22 Seta Tamanivalu, 23 Glen Fisiiahi
Date: Saturday, March 19
Venue: Vélez Sarsfield, Buenos Aires
Kick-off: 18:40 local (21:40 GMT)
Referee: Chris Pollock
Assistant Referees: Jamie Nutbrown, Federico Anselmi
TMO: Santiago Borsani