The Sharks are counting their wounded after they lost 37-10 to the Lions in Johannesburg, with Andre Esterhuizen and Paul Jordaan injured.
Esterhuizen was taken out of the XV that faced the Africa Two winners as he suffered a hamstring problem in a training session on Thursday.
And when they lost fellow centre Jordaan to a knee injury early in the game, the writing seemed on the wall as the Lions cruised to victory.
"He is not good," said Sharks director of rugby Gary Gold about Jordaan's injury after the tough Super Rugby derby fixture at Ellis Park.
"He took a bad knock to the knee early on and it looks like he has done something in his knee … the LCL on the outside or something.
"That didn't make life easier … losing Andre on Thursday and then Paul.
"That centre combination for the whole season was gone within 10 minutes of the game. That's unfortunate, that's the way the coin flips. That's certainly not an excuse."
Gold added that he was hopeful that fly-half Pat Lambie would be fit to return for next week's vital game against the Cheetahs in Durban.
"We were really hoping that Pat might be ready for this week but he wasn't and even up until Wednesday he wasn't showing any signs of improving," he explained.
"The concussion protocol is an important one and we'll always look after our players but hopefully he can come back.
"I don't think Andre will be right, but hopefully he (Lambie) might be coming back and Dan du Preez as well. We'll hold thumbs."