The Reds have made one change to their starting lineup that recorded their first win last week, that will face the Bulls at Loftus on Saturday.
The Queensland side recorded their first win of the season when they beat the defending champions.
Second-rower Ben Matwijow gets his first start of the season when he replaces Rob Simmons with the latter missing out on selection due to injury.
There are also two changes to the bench, lock Lukhan Tui and scrum-half James Tuttle are both set to make their debut should they make an appearance
Tui's inclusion follows Matwijow's promotion to the starting side, while Tuttle has replaced injured Scott Gale.
Reds: 15 Karmichael Hunt 14 Chris Feauai-Sautia, 13 Samu Kerevi, 12 Anthony Fainga'a, 11 Eto Nabuli, 10 Jake McIntyre, 9 Nick Frisby, 8 Jake Schatz, 7 Liam Gill, 6 Hendrik Tui, 5 Ben Matwijow, 4 Cadeyrn Neville, 3 Greg Holmes, 2 Andrew Ready, 1 James Slipper (c)
Replacements: 16 Saia Fainga'a 17 Sef Fa'agase 18 Sam Talakai 19 Lukhan Tui 20 Curtis Browning 21 James Tuttle 22 Sam Greene 23 Ayumu Goromaru
Date: Saturday, April 16
Venue: Loftus Versfeld, Pretoria
Kick-off: 17:05 local (15:05 GMT)
Referee: Angus Gardner
Assistant Referees: AJ Jacobs, tbc
TMO: Johan Greeff