Hooker Malcolm Marx will start for the Golden Lions when they play the EP Kings in Port Elizabeth on Saturday.
Marx and Julian Redelinghuys are both back in the red and white, with Marx returning from Springbok duty while Redelinghuys has recovered from the hamstring injury he sustained in South Africa's win over Argentina in Nelspruit in August.
Other changes up front as part of the rotation system see Bobby De Wee, Ruan Ackermann and Ruaan Lerm come into the forwards while among the backs Dillon Smit, Howard Mnisi, Koch Marx and Sylvian Mahuza are handed starts.
Golden Lions: 15 Sylvian Mahuza, 14 Koch Marx, 13 Jacques Nel, 12 Howard Mnisi, 11 Antony Volmink, 10 Jaco van der Walt, 9 Dillon Smit, 8 Ruaan Lerm, 7 Ruan Ackermann, 6 Kwagga Smith (c), 5 Bobby de Wee, 4 JP du Preez, 3 Julian Redelinghuys, 2 Malcolm Marx, 1 Dylan Smith
Replacements: 16 Robbie Coetzee, 17 Ruan Dreyer, 18 Fabian Booysen, 19 Cyle Brink, 20 Ross Cronje, 21 Rohan Janse van Rensburg, 22 Andries Coetzee
Date: Saturday, September 24
Venue: Nelson Mandela Bay Stadium, Port Elizabeth
Kick-off: 17:10 local (15:10 GMT)
Referee: Cwengile Jadezweni
Assistant Referees: Stuart Berry, Egon Seconds
TMO: Christie du Preez