Scotland prop Darryl Marfo has been ruled out of the first two matches of the Six Nations as he continues his rehabilitation from a back injury.
Scotland are already stretched thin in the loosehead department with Alan Dell sidelined for the first three matches of the Six Nations.
Scotland's opening two fixtures are against Wales and France and losing Marfo, a new find in the Scottish set-up, is a big blow.
The 27-year-old Ediburgh prop has three caps for Scoland, starting in all three games of the fairly recent November International series in which he made his debut.
"Hopefully it will start to settle but at this point there is no return date," Edinburgh coach Richard Cockerill told BBC Sport.
"He is still having treatment and will just continue with his rehab. There is nothing else that needs to be done – no surgical procedure.
"Hopefully he will come back to us as soon as possible."
Meanwhile, on the tighthead side, Scotland will be without WP Nel, who is likely to miss the whole competition with a fractured arm, as well as Zander Fagerson, who will miss the first three rounds.