Maxime Machenaud will start at scrum-half for France ahead of Baptiste Serin for their opening November Test against Samoa.
Machenaud partners François Trinh-Duc in the half-backs, while Louis Picamoles starts at six, combining with Kévin Goudon and Loann Goujon in the back row.
Guilhem Guirado captains the side at hooker, with Jefferson Poirot and Uini Atonio packing down alongside him.
In-form Toulon back-row Charles Ollivon is on the bench, along with Gaël Fickou.
France: 15 Scott Spedding, 14 Yoann Huget, 13 Rémi Lamerat, 12 Wesley Fofana, 11 Virimi Vakatawa, 10 François Trinh-Duc, 9 Maxime Machenaud, 8 Loann Goujon, 7 Kévin Gourdon, 6 Louis Picamoles, 5 Yoann Maestri, 4 Julien Le Devedec, 3 Uini Atonio, 2 Guilhelm Guirado (c), 1 Jefferson Poirot
Replacements: 16 Camille Chat, 17 Cyril Baille, 18 Sébastian Vahaamahina, 19 Charles Ollivon, 20 Baptiste Serin, 21 Jean-Marc Doussain, 22 Gaël Fickou, 23 Rabah Slimani
Date: Saturday, November 12
Venue: Stadium Municipal
Kick-off: 17:45 local (16:45 GMT)
Referee: JP Doyle (England)
Assistant Referees: Craig Joubert (South Africa), Tom Foley (England)
TMO: Stefano Pennè (Italy)