Wales flanker Dan Lydiate believes that England have enough strength in depth to make up for their increasing number of injuries.
Tom Wood, Geoff Parling, Owen Farrell, Kyle Eastmond, Brad Barritt and Luther Burrell were all fresh concerns after the final round of Champions Cup matches for Stuart Lancaster, with more news expected on Tuesday.
Even so, the names already mentioned join a group will miss either some or all of the tournament including Joe Launchbury, Manu Tuilagi, Courtney Lawes, Ben Morgan and Ben Foden.
Lydiate however believes that England will remain a force to be reckoned with when they arrive in Cardiff on February 6 – the start of a tough Six Nations campaign.
“They have got a lot of strength in depth so whatever England side turns up will give a good account of itself,” Lydiate told the Guardian.
“They have got quality throughout their squad and injuries are part of the game today: we have gone through stages where we have picked up a number of them and you have to get on with it.
“It’s a massive game in what promises to be the tightest Six Nations I have been involved in. We have to get our preparations right and build up in a good way.
“The first matches are always important in the Six Nations but there is no bigger way to start than with England. Everyone is ready to get cracking and I am sure the coaches will put us through the mill, as they always do.
“No one is guaranteed his place in the side and that is where you want to be as a squad.”
Lydiate also revealed that he’s looking to evolve as a player following a tough stint in France with Racing M