Marvin Orie will make his debut for the Lions when they take on the Jaguares in Buenos Aires on Saturday.
Shaun Reynolds will also make his first start in Super Rugby at fly-half while Johannes Jonker makes his run-on debut at tighthead prop.
The team shows nine changes to the side that started against the Waratahs and one positional change with Harold Vorster moving from 13 to 12.
In other backline news Anthony Volmink will start on the wing while Jacques Nel starts at outside centre and Jaco van der Walt replaces Andries Coetzee at full-back with Coetzee dropping to the bench.
In the forwards Ruan Ackermann is replaced by Cyle Brink in the seven jersey and Kwagga Smith will start at six at the expense of Jaco Kriel.
Orie comes in place of Franco Mostert and in the front row Jonker and Dylan Smith replaces Ruan Dreyer and Jacques Van Rooyen.
The Lions are resting some star player this weekend with Elton Jantjies, Franco Mostert, Lionel Mapoe and Rohan Janse van Rensburg all missing the trip.
Lions: 15 Jaco van der Walt, 14 Courtnall Skosan, 13 Jacques Nel, 12 Harold Vorster, 11 Anthony Volmink, 10 Shaun Reynolds, 9 Ross Cronjé, 8 Warren Whiteley (c), 7 Cyle Brink, 6 Kwagga Smith, 5 Marvin Orie, 4 Andries Ferreira, 3 Johannes Jonker, 2 Robbie Coetzee, 1 Dylan Smith
Replacments: 16 Malcolm Marx, 17 Jacques van Rooyen, 18 Ruan Dreyer, 19 Lourens Erasmus, 20 Jaco Kriel, 21 Faf de Klerk, 22 Andries Coetzee, 23 Sylvian Mahuza
Date: Saturday, March 11
Venue: Velez Sarsfield, Buenos Aires
Kick-off: 16:40 local (19:40 GMT)
Referee: Nick Briant (New Zealand)
Assistant Referees: Paul Williams (New Zealand), Damian Schneider (Argentina)
TMO: Santiago Borsani (Argentina)