Lions boss Johan Ackermann has made three changes, including a positional switch, to his starting XV for Saturday's clash with the Sharks in Durban.
The Johannesburg-based franchise lost their season opener to the Hurricanes last weekend and all the changes to the run-on side are amongst the forwards.
In the front row, Jacques van Rooyen comes in at loosehead prop in place of Schalk van der Merwe who drops down to the bench.
Additionally, Jaco Kriel has been withdrawn due to the recurrence of a groin injury. As a result, Derick Minnie will start on the openside flank and Warwick Tecklenburg is called up to the starting line-up to fill the blindside berth.
Meanwhile, amongst the replacements, both Robbie Coetzee and Julian Redelinghuys have recovered from their respective injuries and have been called up to cover the hooker and prop berths respectively.
Twenty-year-old lock JP du Preez is set to make his Super Rugby debut should he get a run off the bench. Additionally, Ruaan Lerm will provide loose forward cover and is also a potential debutant.
Centre Harold Vorster has been drafted in and will also make his Super Rugby debut should he play on Saturday. All three of these players have worked their way through the Golden Lions junior ranks.
Lions: 15 Andries Coetzee, 14 Ruan Combrinck, 13 Lionel Mapoe, 12 Howard Mnisi, 11 Courtnall Skosan, 10 Marnitz Boshoff, 9 Ross Cronje, 8 Warren Whiteley (c), 7 Warwick Tecklenburg, 6 Derick Minnie, 5 Franco Mostert, 4 Martin Muller, 3 Ruan Dreyer, 2 Malcolm Marx, 1 Jacques van Rooyen.
Replacements: 16 Robbie Coetzee, 17 Schalk van der Merwe, 18 Julian Redelinghuys, 19 JP du Preez, 20 Ruaan Lerm, 21 Faf de Klerk, 22 Elton Jantjies, 23 Harold Vorster.
Date: Saturday, February 21
Venue: King's Park, Durban
Kick-off: 17:10 local (15:10 GMT)
Referee: Rohan Hoffmann (Australia)
Assistant Referees: Andrew Lees (Australia), Stuart Berry (South Africa)
TMO: Deon van Blommestein (South Africa)