Courtney Lawes has replaced the injured Joe Launchbury in England's squad ahead of the Six Nations match against Ireland at Twickenham on Saturday.
It was anticipated that Launchbury would take part in England’s third game of the tournament but after further consultation with team medical staff it has been decided he is unfit to play.
The lock will now return back to his club (Wasps) for further treatment on a hamstring injury.
Launchbury started against Scotland and was on the bench for the game against Italy.
Forwards: Dan Cole (Leicester Tigers), Jack Clifford (Harlequins), Jamie George (Saracens), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Paul Hill (Northampton Saints), Maro Itoje (Saracens), George Kruis (Saracens), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Chris Robshaw (Harlequins), Billy Vunipola (Saracens), Mako Vunipola (Saracens)
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Owen Farrell (Saracens), George Ford (Bath), Alex Goode (Saracens), Jonathan Joseph (Bath), Jack Nowell (Exeter Chiefs), Anthony Watson (Bath), Ben Youngs (Leicester Tigers)