Sharks fly-half Pat Lambie could miss the start of the Super Rugby season after he injured his shoulder on Friday in a pre-season match in France.
The pivot featured in the Durban side's 29-21 victory over European champions Toulon.
However, the win has come at a cost, with Lambie, Giant Mtyanda, Francois Kleinhans and Ruan Botha all suffering injuries during the clash.
The Springbok fly-half came off the field just before half-time. A full prognosis on his AC joint is still to be made.
"Patrick Lambie, Giant Mtyanda, Francois Kleinhans and Ruan Botha are big losses for us," revealed Sharks director of rugby Gary Gold on the official Sharks website.
"They will all be assessed and we'll know more once the've undergone scans."
Despite the negatives, Gold was happy with how his charges performed against Toulon.
"For a first hit-out, I was really pleased with certain aspects of the game," said Gold.
"I was particularly happy with our composure and the ability to score as many tries as we did.
"There are a couple of areas we still need to work on, but I think by and large we came through the exercise to measure our levels of fitness and physicality quite well, against a seasoned team, already halfway through their season."