Lions openside flanker Jaco Kriel will lead his team in their Super Rugby semi-final against the Highlanders in Johannesburg on Saturday.
Kriel takes over the captaincy from first-choice skipper Warren Whiteley, who has failed to recover from a calf injury sustained in last weekend's quarter-final win over the Crusaders.
Whiteley's absence means that Ruan Ackermann will start at number eight in the only alteration to Lions head coach Johan Ackermann's starting line-up.
Meanwhile, Dillon Smit and Steph de Witt have been included on the replacements bench as scrum-half and back-row cover respectively.
Smit replaces the injured Ross Cronjé while De Witt takes Ackermann's spot on the bench.
Lions: 15 Andries Coetzee, 14 Ruan Combrinck, 13 Lionel Mapoe, 12 Rohan Janse Van Rensburg, 11 Courtnal Skosan, 10 Elton Jantjies, 9 Faf De Klerk, 8 Ruan Ackermann, 7 Warwick Tecklenburg, 6 Jaco Kriel (c), 5 Franco Mostert, 4 Andries Ferreira, 3 Julian Redelinghuys, 2 Malcolm Marx, 1 Dylon Smith
Replacements: 16 Armand van der Merwe, 17 Corné Fourie, 18 Jacques van Rooyen, 19 Lourens Erasmus, 20 Steph de Witt, 21 Dillon Smit, 22 Howard Mnisi, 23 Jaco van der Walt
Date: Saturday, July 30
Venue: Ellis Park Johannesburg
Kick Off local: 15:00 local (13:00 GMT)
Referee: Jaco Peyper
Assistant Referees: Ben O’Keefe, AJ Jacobs
TMO: Shaun Veldsman