Harlequins Director of Rugby John Kingston has lamented the crucial injuries his side suffered in their 24-17 defeat to Worcester on Sunday.
Jack Clifford, Chris Robshaw, Jamie Roberts and George Merrick were all replaced by the start of the second half at Sixways, which disrupted their momentum.
"There was enormous amount of disruption for us with a number of our leading players gone by half-time," Kingston said after the game.
"Chris should have come off when he had the bang but bravery kept him out there as we were in a mess. Our medics will report to England, they are due down there at noon tomorrow, so he'll probably go regardless.
"Jack has concussion, George failed a head injury assessment, so they are both doubtful for next week, while Jamie has a cut leg and aggravated something."
Worcester led 21-0 at one stage, but Quins launched a fightback in the second half with tries from Charlie Matthews and Alofa Alofa, with Tim Swiel adding seven points with the boot, but it wasn't enough.
"We've got to be more competitive though we were excellent in the last 15 minutes," Kingston said.
"We deserve to be where we are in the table as we are too inconsistent, we have tried to change our preparation for away games but it didn't work as we had a poor start.
"Worcester played really well as there are no weak sides in the division and there was no shock in their ability to perform."