Italy have called in Mauro Bergamasco and Marco Bortolami for their Six Nations clash with England at Twickenham on Saturday.
The duo replace Alessandro Zanni and Joshua Furno in the side at blindside flanker and lock respectively while Albert De Marchi comes in for Matias Aguero at loosehead prop.
Jacques Brunel has also made some alterations to his backline as Andrea Masi comes into the centres alongside Luca Morisi due to Michele Campagnaro's injury. Giovambattista Venditti is on the left wing, with Luke McLean moving to full-back for the game.
Italy lost their Six Nations opener 26-3 to Ireland.
Italy: 15 Luke McLean, 14 Leonardo Sarto, 13 Luca Morisi, 12 Andrea Masi, 11 Giovambattista Venditti, 10 Kelly Haimona, 9 Edoardo Gori, 8 Sergio Parisse, 7 Francesco Minto, 6 Mauro Bergamasco, 5 Marco Bortolami, 4 George Fabio Biagi, 3 Martin Castrogiovanni 2 Leonardo Ghiraldini, 1 Alberto De Marchi.
Replacements: 16 Andrea Manici, 17 Matias Aguero, 18 Dario Chistolini, 19 Joshua Furno, 20 Samuela Vunisa, 21 Guglielmo Palazzani, 22 Tommaso Allan, 23 Giulio Bisegni.
Date: Saturday, February 14
Kick-off: 14:30 GMT
Referee: Johnny Lacey (Ireland)
Assistant referees: Pascal Gauzère (France), Mike Fraser (New Zealand)
Television match official: George Ayoub (Australia)
Assessor: Lyndon Bray (New Zealand)