Italy will be without first-choice fly-half Kelly Haimona at the World Cup after he failed to recover from a broken arm in time.
The Zebre fly-half broke his arm in Italy's Six Nations finale against Wales and the fracture has taken longer than expected to heal.
And having initially been named in the squad for the tournament, the decision has been taken to release him with Tommaso Allan and the uncapped Carlo Canna, the two fly-halves left in the squad.
"Since he started in the national team last November, Kelly has been a key element in the Italy team," said Italy coach Jacques Brunel.
"So it wasn't easy to choose to do without him over the next two months. However, we are preparing for a World Cup and we have to work with those who we can rely on from a physical perspective. Kelly will join us during the World Cup if it's possible and if we need him."
"For me it's a difficult day: I can see a dream getting away, of appearing in the most important competition in our sport, an objective I've been pursuing for years," said Haimona.
"But I understand and share Jacques' position, and that of all the staff. I wish the players all the best, in particular Tommy and Carlo Canna.
"I will keep working in Parma, at my club, to be ready if it's necessary."