Rob Horne has recovered from injury and has been included in the Waratahs' starting line-up for the clash with the Southern Kings in Sydney on Friday.
Horne has been picked at outside centre while Israel Folau moves to full-back.
Moving into the starting line up at lock is David McDuling, while Dean Mumm moves to the bench.
Angus Ta’avao will also make his return, after being sidelined for six months when he broke his leg during the NRC Semi-Final.
Andrew Kellaway has been sidelined after sustaining a fracture in small bone (hyoid) on the weekend playing in club rugby.
He was admitted to hospital for observation. While he won't require surgery, it will rule him out for 3-6 weeks.
Waratahs: 15 Israel Folau, 14 Taqele Naiyaravoro, 13 Rob Horne, 12 David Horwitz, 11 Cam Clark, 10 Bernard Foley, 9 Jake Gordon, 8 Michael Wells, 7 Michael Hooper (captain), 6 Ned Hanigan, 5 Will Skelton, 4 David McDuling, 3 Tom Robertson, 2 Tolu Latu, 1 Paddy Ryan
Replacements: 16 Hugh Roach, 17 Angus Taavao, 18 David Lolohea, 19 Dean Mumm, 20 Jed Holloway, 21 Nick Phipps, 22 Bryce Hegarty, 23 Harry Jones
Date: Friday, April 21
Venue: Allianz Stadium, Sydney
Kick-off: 19.45 local (09.45 GMT)
Referee: Rohan Hoffmann (Australia)
Assistant Referees: Damon Murphy (Australia), James Leckie (Australia)
TMO: Ian Smith (Australia)