Former England Sevens international Jack Wilson has been named on the wing for the Highlanders against the Rebels.
Wilson, 26, featured for the Sharks in Super Rugby last year and has played for Otago in the NPC. He replaces Matt Faddes, who has a hamstring strain.
Experienced wing Patrick Osborne returns on the left wing for the Highlanders in place of Ryan Tongia.
Joe Wheeler and Luke Whitelock have both recovered from injuries to be named in the Highlanders' pack, with Whitelock starting on the blindside in place of Elliot Dixon who drops down to the bench.
Wheeler starts at lock while there is also a change at hooker where Ash Dixon takes over from Liam Coltman.
Highlanders: 15 Ben Smith (cc), 14 Jack Wilson, 13 Malakai Fekitoa, 12 Rob Thompson, 11 Patrick Osborne, 10 Lima Sopoaga, 9 Aaron Smith, 8 Liam Squire, 7 Shane Christie (cc), 6 Luke Whitelock, 5 Joe Wheeler, 4 Mark Reddish, 3 Siosuia Halanukonuka, 2 Ash Dixon, 1 Brendon Edmonds
Replacements: 16 Liam Coltman, 17 Craig Millar, 18 Josh Hohneck, 19 Dan Pryor, 20 Elliot Dixon, 21 Josh Renton, 22 Hayden Parker, 23 Jason Emery
Date: Saturday, March 26
Venue: AAMI Park, Melbourne
Kick-off: 19:45 local (08:45 GMT)
Referee: Andrew Lees
Assistant Referees: Angus Gardner, Jordan Way
TMO: Peter Marshall