Robbie Henshaw will make his first appearance of the World Cup after being named at centre for Ireland's clash with Italy on Sunday.
The Connacht back has shaken off a hamstring problem and links up with Keith Earls in midfield as regular partner Jared Payne misses out through injury.
Rob Kearney is also out, with Simon Zebo earning the nod at full-back, while Tommy Bowe did enough against Romania to get a starting spot at the Olympic Stadium.
Elsewhere it's as expected with a first-choice pack that features Iain Henderson in the second row, preferred to Devin Toner. Jack McGrath returns at loosehead with Cian Healy dropping to the bench having only made his return from injury against the Oaks.
Paul O'Connell skippers the side while on the bench Sean Cronin gets the nod at hooker and Chris Henry will cover the back row.
Ireland: 15 Simon Zebo, 14 Tommy Bowe, 13 Keith Earls, 12 Robbie Henshaw, 11 Dave Kearney, 10 Johnny Sexton, 9 Conor Murray, 8 Jamie Heaslip, 7 Sean O'Brien, 6 Peter O'Mahony, 5 Paul O'Connell (c), 4 Iain Henderson, 3 Mike Ross, 2 Rory Best, 1 Jack McGrath
Replacements: 16 Sean Cronin, 17 Cian Healy, 18 Nathan White, 19 Devin Toner, 20 Chris Henry, 21 Eoin Reddan, 22 Ian Madigan, 23 Luke Fitzgerald
Date: Sunday, October 4
Venue: Olympic Stadium, London
Kick-off: 16:45 local
Referee: Jérôme Garcès (France)
Assistant Referees: Pascal Gauzère (France), Angus Gardner (Australia)
TMO: Graham Hughes (England)