Harlequins has made a change to the team to play Stade Français in round six of the European Challenge Cup in Paris.
James Horwill failed a fitness test on Friday evening and has been withdrawn from the squad.
Charlie Matthews now starts in the second row, with Dave Ward called into the replacements.
Harlequins: 15 Mike Brown, 14 Marland Yarde, 13 Matt Hopper, 12 Jamie Roberts, 11 Tim Visser, 10 Tim Swiel, 9 Danny Care(c), 8 Mat Luamanu, 7 Luke Wallace, 6 Jack Clifford, 5 Charlie Matthews, 4 George Merrick, 3 Kyle Sinckler, 2 Rob Buchanan, 1 Dan Murphy
Replacements: 16 Joe gray, 17 owen evans, 18 adam jones, 19 james chisholm, 20 dave ward, 21 karl dickson, 22 ruaridh jackson, 23 alofa alofa
Referee: George Clancy (Ireland)
Assistant Referees: Leo Colgan (Ireland), Mark Patton (Ireland)
TMO: Brian MacNeice (Ireland)