Glasgow Warriors will kick off the defence of their Guinness PRO12 title at home to the Scarlets, while last season's beaten finalists Munster host Treviso.
With the PRO12 fixtures released, all 12 clubs can begin to finalise their plans for 2015/16, which promises to be another exhilarating season.
The campaign kicks off on Friday, September 4 with last season's beaten semi-finalists – Ulster and Ospreys – going head-to-head at Kingspan Stadium, and Leinster visiting Edinburgh.
Scarlets go to Scotstoun the following day, while Munster face Treviso, Zebre travel to Cardiff Arms Park to take on the Blues and Connacht clash with the Dragons on the opening weekend.
The festive period sees the return of the 1872 Cup, with Edinburgh and the Warriors meeting at Murrayfield on December 27 and then again at Scotstoun on January 2.
And there are plenty of other local derbies across rounds 10 and 11, with four all-Welsh clashes, four all-Irish encounters and Treviso locking horns with Zebre twice in quick succession.
The final round of regular-season action will take place across the weekend of May 6-8 but for the league's top four sides, the run-in will have only just begun.
Two weeks later sees the Play-Offs kick off, while the PRO12 Final will be the following weekend, when the champions will lift the coveted trophy.