France have been dealt another midfield blow with the news that Toulouse centre Yann David has been ruled out for the opening rounds.
David was one of the surprise selections by Guy Novès, ending an international exile going back to 2009.
Midi Olympique reported on Wednesday that David is now out of France's opening match with England this Saturday at Twickenham due to a thigh injury.
David underwent a scan on Wednesday which suggested he would require two weeks' rest, which would also seem to rule him out of facing Scotland the following week.
France are already without Wesley Fofana for the entire tournament due to injury, leaving Novès to choose from Gaël Fickou, Rémi Lamerat and Mathieu Bastareaud.