France have made 13 changes to their starting XV for this Wednesday's clash with Romania at the Olympic Stadium in London.
Noa Nakaitaci and Louis Picamoles are the only two survivors from last Saturday's win over Italy.
Dimitri Szarzewski will captain the side from hooker with Thierry Dusautoir rested from the matchday squad.
Clermont star Wesley Fofana has recovered from injury to start at inside centre, forming a new partnership with Gaël Fickou.
Back-row Bernard le Roux is set to start in the second row alongside Alexandre Flanquart, with Rémi Talès taking over at fly-half from Frédéric Michalak who scored 19 points against Italy with the boot.
Nicolas Mas is named on the bench for the second game in a row, despite scoring his first ever Test try in his 81st cap last weekend, as Uini Atonio gets the nod.
France: 15 Brice Dulin, 14 Sofiane Guitoune, 13 Gaël Fickou, 12 Wesley Fofana, 11 Noa Nakaitaci, 10 Rémi Talès, 9 Morgan Parra, 8 Louis Picamoles, 7 Fulgence Ouedraogo, 6 Yannick Nyanga, 5 Alexandre Flanquart, 4 Bernard le Roux, 3 Uini Atonio, 2 Dimitri Szarzewski (c), 1 Vincent Debaty
Replacements: 16 Benjamin Kayser, 17 Eddy Ben Arous, 18 Nicolas Mas, 19 Yoann Maestri, 20 Damien Chouly, 21 Rory Kockott, 22 Frédéric Michalak, 23 Mathieu Bastareaud
Date: Saturday, September 23
Venue: Olympic Stadium, London
Kick-off: 20:00 local
Referee: Jaco Peyper (South Africa)
Assistant Referees: Craig Joubert (South Africa), Federico Anselmi (Argentina)
TMO: George Ayoub (Australia