France look set to be without centre Wesley Fofana for their opening World Cup game against Italy at Twickenham on Saturday.
The Clermont centre, appearing in his first World Cup, went off during France's win over Scotland earlier this month with a thigh injury.
According to RMC Sport, he has done everything possible to get back for the opener against the Azzurri, but the fortnight's rest has not been sufficient.
As a result les Bleus won't take any chances, and Alexandre Dumoulin is in line to replace Fofana in the starting line-up.
That would see Gaël Fickou brought onto the bench to provide cover in the three-quarters for France.
Philippe Saint-André had previously explained that his squad are already preparing for both their clash with Italy, and the following game against Romania four days later, with a number of players having been told they won't feature on Saturday.