England have made eight changes for their final match of World Cup 2015 against Uruguay, with seven players making their first starts of the tournament.
George Ford returns to fly-half, the position where he began the tournament against Fiji, while Alex Goode at full-back, Henry Slade at outside centre, Jack Nowell on the left wing, Danny Care at scrum-half, Nick Easter at number eight, James Haskell on the blindside flank and Mako Vunipola at loosehead, will all start for the first time at RWC 2015.
Four of them – Care, Nowell, Slade and Goode – will all play their first ever RWC matches, as will hooker Jamie George if he comes off the bench. Prop David Wilson is also named on the bench, and will add to his 40 minutes of RWC experience from 2011 if he gets on the field.
RWC experience has been a long time coming for Care who was ruled out of selection less than a month before the start of RWC 2011 after breaking the big toe on his left foot during the 19-9 warm-up defeat by Wales in Cardiff.
Despite 29 Test caps, Mako Vunipola makes just his fifth start for England, and the prop has a 100 per cent success record when in the run-on side.
Despite the inclusion of three of the squad's five 50-cappers – Haskell (61), Easter (53) and Care (52) – the starting team has a total of 475 international caps, with only the opening-match team against Fiji (470) boasting fewer at RWC 2015.
Other than Fiji, the last RWC match where England had a starting XV with fewer caps (460) was the 36-0 defeat by South Africa at RWC 2007, a match that both England coaches Andy Farrell (12) and Mike Catt (10) started.
England: 15 Alex Goode, 14 Anthony Watson, 13 Henry Slade, 12 Owen Farrell, 11 Jack Nowell, 10 George Ford, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 James Haskell, 5 Geoff Parling, 4 Joe Launchbury, 3 Dan Cole, 2 Tom Youngs, 1 Mako Vunipola.
Replacements: 16 Jamie George, 17 Joe Marler, 18 David Wilson, 19 George Kruis, 20 Tom Wood, 21 Richard Wigglesworth, 22 Jonathan Joseph, 23 Mike Brown.
Date: Saturday, October 10
Venue: Manchester City Stadium, Manchester
Kick-off: 20:00 local
Referee: Chris Pollock (New Zealand)
Assistant referees: Angus Gardner (Australia), Federico Anselmi (Argentina)
Television match official: George Ayoub (Australia)
Timekeeper: Jon Mason (Wales)