Faf de Klerk is set to make his 50th appearance for the Pumas as they take on the Eastern Province Kings at Mbombela Stadium on Friday.
A number of players return for the Pumas including Springbok tighthead Vincent Koch and skipper Stefan Watermeyer, who have both shaken off knocks.
Frank Herne replaces Francois du Toit at hooker and Jaco Bouwer is preferred to Uzair Cassiem in the back-row.
Marius Coetzer gets the nod in the second-row, and Jerome Pretorius shifts to the wing in place of the absent Bernado Botha.
Pumas: 15 Hoffmann Maritz, 14 Jerome Pretorius, 13 Wilmaure Louw, 12 Stefan Watermeyer (c), 11 Rosco Spekman, 10 Justin van Staden, 9 Faf de Klerk, 8 Jason-Colin Fraser, 7 Uzair Cassiem, 6 Marnus Schoeman, 5 Marius Coetzer, 4 Rudi Mathee/Lubabalo Mtyanda, 3 Vincent Koch, 2 Frank Herne, 1 Corné Fourie.
Replacements: 16 Simon Westraadt, 17 De-Jay Terblanché/Marné Coetzee, 18 Lubabalo Mtyanda/Jannie Stander, 19 Uzair Cassiem, 20 Reynier van Rooyen, 21 Hennie Skorbinski, 22 Marcello Sampson.
Date: Friday, September 18
Venue: Mbombela Stadium, Nelspruit
Kick-off: 17:00 local (15:00 GMT)
Referee: Cwengile Jadezweni
Assistant referees: Marius van der Westhuizen, Stephan Geldenhuys
TMO: Willie Vos