Reigning European champions, Toulon, could make a return to the Stade Vélodrome for their Champions Cup semi-final if they manage to defeat Wasps in Sunday's crunch quarter-final.
Toulon got the better of Munster in last season's semi-final at the iconic Marseille stadium which has been completely redeveloped, and they are targeting another big day against either Leinster or Bath as they bid for an historic three European titles in a row.
Should Wasps dethrone the champions, they will take on Leinster or Bath in the last four at the AMEX Community Stadium in Brighton with the semi-finals scheduled for the weekend of 18/19 April.
The Brighton stadium is one of the venues for Rugby World Cup 2015 and recently hosted the Six Nations U20 match between England and France.
If Clermont add to an impressive 22-game unbeaten home run in Europe when they meet Northampton Saints on Saturday, they will play either Racing Métro or Saracens in the semi-final at Stade Geoffroy-Guichard in Saint-Etienne.
However, should Saints come away from Clermont with a victory, they will meet either Racing or Saracens at the Ricoh Arena in Coventry.
The exact dates and kick-off times for the Champions Cup semi-finals will be announced following the quarter-finals. Tickets will be sold through the competing clubs and will also be on general sale.
The Champions Cup semi-finals are played at venues designated by EPCR which are selected in conjunction with the relevant Union. Home country advantage in the last four was determined by a draw at the conclusion of the pool stages in January.
For the Challenge Cup, the semi-finals are played at home venues with home advantage also decided by the draw in January.
The inaugural knockout stages of EPCR's tournaments will kick off on Friday when Gloucester meet Connacht in the first of the Challenge Cup quarter-finals, with the Champions Cup last-eight games getting underway the following day when Leinster go head-to-head with Bath.
Champions Cup semi-finals – 18/19 April
Toulon v winners Leinster v Bath
Stade Vélodrome, Marseille (capacity: 62,895)
Wasps v winners Leinster v Bath
AMEX Community Stadium, Brighton (capacity: 30,750)
Clermont v winners Racing Métro v Saracens
Stade Geoffroy-Guichard, Saint-Etienne (capacity: 39,774)
Northampton Saints v winners Racing Métro v Saracens
Ricoh Arena, Coventry (capacity: 32,609)
Challenge Cup semi-finals – 17/18/19 April
Gloucester or Connacht v Exeter Chiefs or Newcastle Falcons
Kingsholm Stadium or The Sportsground
London Irish or Edinburgh v Newport Gwent Dragons or Cardiff Blues
Madejski Stadium or Murrayfield Stadium