Eben Etzebeth will return to South Africa on Tuesday after failing to recover from concussion in time for South Africa's final tour game against Wales.
The lock suffered concussion against England at Twickenham and has not recovered quick enough to be considered for the game against Wales.
"We won’t call up a replacement because we currently have sufficient cover in that position with Pieter-Steph du Toit, Lood de Jager and Franco Mostert,” explained Springbok coach Allister Coetzee.
"There are also some utility forwards who can provide extra cover if needed."
Coetzee also confirmed that there were no other major injury concerns and the rest of the squad was fit and available for selection.
The Boks didn't have any training on Monday with heavy rain in Cardiff.
"We want to ensure the players have time to put the disappointment of the Italy result behind them. I want there to be enthusiasm on Saturday and for us to put in a good performance," Coetzee explained.
The under-fire Bok coach also confirmed he will be looking to give other players a chance against Wales.
"My philosophy for the game against Italy was to keep continuity after our Test against England and win. We didn't, so I have to give other players an opportunity.
"There is a plan for the way forward and we have to see if the younger players can cope at this level. There are players who have worked hard and deserve a chance."