Springbok flanker Jean Deysel will captain the Sharks when they host the Western Force in Durban on Saturday.
Deysel who returns to the side in the absence of Marcell Coetzee who is being rested, takes over the captaincy due to the suspension of Springbok hooker Bismarck du Plessis.
Amongst the forwards Mouritz Botha and Beast Mtawarira, both of whom took heavy blows from the Chiefs, have been passed fit to play. Kyle Cooper taking over at hooker is the only other change amongst the forwards.
Backline changes have been made in the midfield, the resting of Springboks Cobus Reinach and Pat Lambie have necessitated a new halfback pairing for the first time this season, Conrad Hoffmann taking over at scrum-half and Frans Steyn shifting from centre to fly-half.
Andre Esterhuizen earns his second start, he will partner JP Pietersen from inside centre.
Sharks: 15 SP Marais, 14 Odwa Ndungane, 13 JP Pietersen, 12 Andre Esterhuizen, 11 Lwazi Mvovo, 10 Frans Steyn, 9 Conrad Hoffmann, 8 Ryan Kankowski, 7 Jean Deysel (c), 6 Renaldo Bothma, 5 Marco Wentzel, 4 Mouritz Botha, 3 Jannie du Plessis, 2 Kyle Cooper, 1 Tendai Mtawarira.
Replacements: 16 Monde Hadebe, 17 Thomas du Toit, 18 Lourens Adriaanse, 19 Lubabalo Mtyanda, 20 Daniel du Preez, 21 Stefan Ungerer, 22 Fred Zeilinga, 23 Waylon Murray.
Date: Saturday, March 28
Kick-off: 17:05 local (15.05 GMT, 04.05 NZST, 02.05 AEST)
Venue: Kings Park Stadium, Durban
Referee: Nick Briant (New Zealand)
Assistant referees: Jason Jaftha (South Africa), Quinton Immelman (South Africa)
Television match official: Marius Jonker (South Africa)