Scrum-half Sam Hidalgo-Clyne knows a win over England could set Scotland on course for a historic year.
Scotland haven't won the Six Nations since 1999 and the last time they lifted the Calcutta Cup was back in 2008.
However there is plenty of optimism around Vern Cotter's side after their impressive performances at the Rugby World Cup, when they narrowly missed out on making the semi-finals.
Hidalgo-Clyne won his first cap for Scotland during last year's Six Nations and he believes the squad are mentally in the right place coming into the competition.
"If we can get one over England, that gives us a huge confidence booster and we are right there in the mix," Hidalgo-Clyne told the Six Nations website.
"If we were to lose, that would obviously be a step back. For us, that is not really an option at the moment. We have not really thought about losing.
"We have definitely developed as a squad and the mind-set had to change.
"Tournaments are physically and mentally draining and you have to get your mindset right. We need to start this tournament on a real high and go out with full confidence for this first game.
"We are at home, we have got a brilliant squad, a very settled squad and England are not by any means, so there is no reason why we can't.
"One thing Scotland hasn't had much success with previously is believing in ourselves.
"But this is one of the most dangerous teams Scotland have had. There is huge confidence around the squad and we have to take that and believe in ourselves.
"The tickets were sold out months ago, the fans are going to be right behind us and we are really looking forward to next week."