Springbok head coach Allister Coetzee has made two injury-enforced changes to his run-on side for Saturday's clash with the All Blacks in Durban.
Faf de Klerk comes in at scrum-half in place of Rudy Paige while Damian de Allende replaces Jesse Kriel in midfield.
In a positional change in midfield, Juan de Jongh moves from inside to outside centre, with De Allende now wearing the number 12 jersey. The two wings, Bryan Habana and Francois Hougaard, will swap jerseys for this Test.
The rest of the matchday squad was kept unchanged from the line-up that defeated the Wallabies in Pretoria last Saturday.
"Unfortunately for Rudy, he will not have completed his gradual return to play protocol by this weekend, which gives Faf another opportunity in the number nine jersey," said Coetzee.
"Damian should slot in well next to Juan de Jongh in the midfield as they play together for their Super Rugby franchise."
According to Coetzee, the bench made a very good impact against the Wallabies. "I expect them to do a similar job this coming weekend," he added.
"Furthermore, our set-piece have functioned very well and I am hoping for the same against a very good defensive lineout and scrum from the All Blacks.
"The All Blacks will be a huge Test, they are number one side in the world and they have great form at the moment. We are playing at home and the boys are looking forward to the encounter against the world’s best team.
"It is important for us to end the campaign with a good performance against a very good All Blacks side. What I would like to see is that that we keep on improving as a team and build on our continuity and converting more of our opportunities into points."
The match will be the last home Test match for Springbok hooker Adriaan Strauss, who will retire from international rugby at the end of the season.
New Zealand have already won the 2016 Rugby Championship and a positive result will enable the South Africans to finish in second place.
South Africa: 15 Patrick Lambie, 14 Francois Hougaard, 13 Juan de Jongh, 12 Damian de Allende, 11 Bryan Habana, 10 Morne Steyn, 9 Faf de Klerk, 8 Warren Whiteley, 7 Teboho Mohoje, 6 Francois Louw, 5 Pieter-Steph du Toit, 4 Eben Etzebeth, 3 Vincent Koch, 2 Adriaan Strauss (c), 1 Tendai Mtawarira
Replacements: 16 Bongi Mbonambi, 17 Stephen Kitshoff, 18 Julian Redelinghuys, 19 Lood de Jager, 20 Willem Alberts, 21 Jaco Kriel, 22 Lionel Mapoe, 23 Willie le Roux
Date: Saturday, October 8
Venue: Kings Park, Durban
Kick-off: 17:05 local (15:05 GMT)
Referee: Jérôme Garcès (France)
Assistant Referees: Johnny Lacey (Ireland), George Clancy (Ireland)
TMO: Jim Yuille (Scotland)