Damian de Allende will make his return to the Stormers starting line-up ahead of Saturday's meeting with the Reds at Newlands.
Head coach Robbie Fleck has made four changes in addition to the De Allende adjustment. The 24-year-old Springbok centre will partner with Johnny Kotze in the midfield.
Co-captain Juan de Jongh is being rested after sustaining a concussion during his side's 29-22 loss to the Lions last week.
Scrum-half Nic Groom will make his 50th Super Rugby appearance for the Cape side.
Frans Malherbe returns to the starting XV and will captain the side. He is joined by Oli Kebble in the front-row, with Vincent Koch and JC Janse van Rensburg named on the replacements bench.
Rynhardt Elstadt makes his first start of the season in the second-row, with JD Schickerling named on the bench, Siya Kolisi comes in for Schalk Burger, who is also seen amongst the replacements and Nizaam Carr moves to number eight in one of four positional shifts.
Stormers: 15 Cheslin Kolbe, 14 Kobus van Wyk, 13 Johnny Kotze, 12 Damian de Allende, 11 Leolin Zas, 10 Jean-Luc du Plessis, 9 Nic Groom, 8 Nizaam Carr, 7 Siya Kolisi, 6 Sikhumbuzo Notshe, 5 Pieter-Steph du Toit, 4 Rynhardt Elstadt, 3 Frans Malherbe (c), 2 Bongi Mbonambi, 1 Oli Kebble
Replacements: 16 Mike Willemse, 17 JC Janse van Rensburg, 18 Vincent Koch, 19 JD Schickerling, 20 Schalk Burger, 21 Louis Schreuder, 22 Huw Jones, 23 Brandon Thomson
Date: Saturday, 23 April
Venue: DHL Newlands, Cape Town
Kick-off: 15:00 local (13:00 GMT)
Referee: Marius van der Westhuizen
Assistant referees: Quinton Immelman; Cwengile Jadezweni
TMO: Shaun Veldsman