Former Waratahs wing Cam Crawford will become the 84th player to represent the Rebels after he was named to start against the Stormers in Cape Town on Saturday.
Rebels coach Tony McGahan was forced into three changes to his starting line-up, as Tamati Ellison (groin), Sefanaia Naivalu (concussion) and Toby Smith (back) miss out, but flanker Scott Fuglistaller returns to the starting line-up.
Cruze Ah-Nau will make his first start of 2015 at loosehead prop after featuring off the bench in every match this season, while Tom English returns to the starting line-up on the left wing.
Dom Shipperley will again play outside centre, after playing there against the Blues in Round 13, while Japanese international prop Keita Inagaki is named on a Super Rugby bench for the first time and could become the third Japanese international to represent the Rebels.
Melbourne Rebels: 15 Mike Harris, 14 Cam Crawford, 13 Dom Shipperley, 12 Mitch Inman, 11 Tom English, 10 Jack Debreczeni, 9 Nic Stirzaker, 8 Scott Higginbotham, 7 Scott Fuglistaller, 6 Sean McMahon, 5 Lopeti Timani, 4 Luke Jones, 3 Paul Alo-Emile, 2 Pat Leafa, 1 Cruze Ah-Nau.
Replacements: 16 Tom Sexton, 17 Keita Inagaki, 18 Laurie Weeks, 19 Cadeyrn Neville, 20 Jordy Reid, 21 Colby Fainga’a, 22 Luke Burgess, 23 Bryce Hegarty.
Date: Saturday, 23 May
Venue: Newlands, Cape Town
Kick-off: 19:10 local (17:10 GMT, 03:10 AEST, 05:10 NZST)
Referee: Stuart Berry (South Africa)
Assistant referees: Quinton Immelman (South Africa), Rodney Boneparte (South Africa)
Television match official: Deon van Blommestein (South Africa)