London Irish boss Tom Coventry says the coaching staff will do everything this week to lift the squad after a heavy away loss to Harlequins.
The Exiles sit in bottom place in the Premiership after six losses from their opening six games, with no points to their name.
The most recent of those was last Saturday with a 38-7 defeat to old rivals Harlequins.
Coventry now hopes the side can use the Challenge Cup as a springboard to improve their fortunes after a tough start to the season.
“We need to keep focused on the things that we have been working on and continue to work hard," Coventry told the club's website.
"Picking the guys up is important, after a number of losses confidence can be down so we need to try and find a way to get them up and then focus on Edinburgh and see what we can do there.”
Matt Symons, a big-name signing from Super Rugby outfit the Chiefs over the off-season, is expected to return after having to withdraw from the starting XV late before kick-off last weekend.
“Matt’s had a big workload and has been pretty inspiring for the boys," Coventry added.
"Obviously George [Skivington] has been out for a few weeks now so losing a couple of captains isn’t ideal, but injuries and disruption is part and parcel of the game. We hope to have Matt back this week and George in the coming weeks.”