Reds head coach Nick Stiles has made six changes to his starting XV to face the Southern Kings in their first-ever Super Rugby clash, in Brisbane on Saturday.
Quade Cooper has returned from a three-week suspension due to a high tackle and resumes the role of starting flyhalf, while Karmichael Hunt has recovered from a concussion suffered two weeks ago to start at full-back.
The only other change to the back-line is the promotion of Izaia Perese to starting wing, with Chris Kuridrani shifted to the bench.
In the forwards, hooker Alex Mafi has earned his first start in Super Rugby after making his debut for Queensland off the bench last weekend.
Andrew Ready returns to the side in the reserves, with Stephen Moore left out of the matchday 23. Centre Samu Kerevi will captain the side in Moore’s absence.
Lock Lukhan Tui has earned his first start of the 2017 season, in place of Kane Douglas, who is on the bench.
The other change to the pack sees Japanese Test player Hendrik Tui return to starting blindside flanker, with Adam Korczyk moved to the reserves.
Nick Frisby has also returned to the matchday 23 as reserve scrum-half.
This weekend’s match will also feature a significant milestone for veteran flanker George Smith, who becomes just the seventh player in the history of the competition and only the third Australian player to reach 150 Super Rugby caps.
Stiles said: “It’s great to welcome Quade and Karmichael back into the starting side. They’re both experienced leaders and are desperate to help guide the team to a win this weekend.
“It’s also a significant match for George. He’s been a great influence since joining the team, is one of the greatest players Australia has ever produced, and it would be nice to celebrate his milestone with a win.
“One of the strengths of this squad is its depth and we’re continuing to test that and develop experience within the younger players. As we’ve done with other players, we felt it was necessary to manage Stephen’s workload throughout the year, which is why he’s not taking part in this match.
“This is an important game for us. We’re back at our home ground and the team is keen to bounce back from a disappointing performance last weekend.”
Reds: 15 Karmichael Hunt, 14 Izaia Perese, 13 Samu Kerevi (c), 12 Duncan Paia’aua, 11 Eto Nabul, 10 Quade Cooper, 9 James Tuttle, 8 Scott Higginbotham, 7 George Smith, 6 Hendrik Tui, 5 Lukhan Tui, 4 Rob Simmons, 3 Sam Talakai, 2 Alex Mafi, 1 Sef Fa’agase
Replacements: 16 Andrew Ready, 17 Kirwan Sanday , 18 Taniela Tupou, 19 Kane Douglas, 20 Adam Korczyk, 21 Nick Frisby, 22 Hamish Stewart, 23 Chris Kuridrani
Date: Saturday, April 15
Venue: Suncorp Stadium, Brisbane
Kick-off: 17:05 local (05:05 GMT)
Referee: Quinton Immelman
Assistant Referees: Rasta Rasivhenge, Damon Murphy
TMO: Damien Mitchelmore