Fly-half AJ MacGinty has been ruled out for a month after he injured his shoulder in Connacht's 7-6 win over Leinster at Sportsground on Saturday.
The USA international – who made his debut for the Eagles in the Pacific Nations Cup in 2015 – has made 13 appearances for the Irish province since joining them after the World Cup.
Connacht are four points clear at the top of the PRO12 table with matches against Ulster, Munster and bottom seeded Treviso with a European Challenge Cup fixture away to Grenoble on April 9 still to come over the next few weeks.
Head coach Pat Lam said that despite losing another back-line player to injury he is backing the current squad to fill the void left by the sidelined players.
"You can’t control the injuries," Lam told The42.
"Of course we would love to have Jack, Craig and AJ available but you can’t cry over that, you just have to live on and the next person puts the jersey on and steps into the role.
"The number one thing is understanding the role and the next person putting on that jersey it’s his job to do it."
Lam made notable mentions of players that have already stepped up into key positions.
"You saw where Caoilin Blade (scrum-half) had to step in at the last minute at out-half and Shane O’Leary move to 12 and Robbie Henshaw back to full-back, a lot of the backs, and the forwards, can play more than one position.
"And that’s important, they have to make sure they know the role and the beauty of having our team game, it’s actually a simple game what we can do and some guys can move in different positions and pick up that particular role."