RC Enisei continued with their fine start to the tournament when they beat the Dragons while Gloucester, Edinburgh, Brive and Ospreys won.
RC Enisei 38-18 Dragons
The home side continued where they left off against Worcester Warriors last weekend and outscored the Dragons by five tries to two to register their second successive win.
Dmitrii Gerasimov and Stanislav Selskiy both crossed for a brace of tries but, like last weekend, Yury Kushnarev led the way for RC Enisei as he contributed 13 points in their win, courtesy of five conversions and a penalty.
Kushnarev opened the scoring with a penalty in the 17th minute before the Dragons struck back via a Pat Howard try two minutes later which Angus O'Brien converted.
Gerasimov then crossed for his first try on the half-hour mark but Sam Beard replied with a try of his own shortly afterwards before Selskiy dotted down shortly before half-time.
The visitors took the lead by the hour-mark after O'Brien added two further penalties but the final quarter was a one-sided affair as RC Enisei took control of proceedings.
Further tries from Gerasimov and Selskiy proved decisive before Valery Morozov sealed victory with a five-pointer in the game's closing stages.
For RC Enisei:
Tries: Gerasimov 2, Selskiy 2, Morozov
Cons: Kushnarev 5
Tries: Howard, Beard
Pens: O'Brien 2
RC Enisei: 15 Ramil Gaisin, 14 Igor Kurashov, 13 David Kacharava, 12 Thomas Halse, 11 Denis Simplikevich, 10 Iurii Kushnarev, 9 Alexey Shcherban, 8 Anton Rudoi, 7 Vitalii Orlov, 6 Mikheil Gachechiladze, 5 Maxim Gargalic, 4 Uldis Saulite, 3 Innokentiy Zykov, 2 Stanislav Selskii, 1 Andrei Polivalov
Replacements: 16 Shamil Magomedov, 17 Valery Morozov, 18 Evgenii Pronenko, 19 Tagir Ghadgiev, 20 Jurijs Baranovs, 21 Konstantin Uzunov, 22 Aleksei Mikhaltsov, 23 Viacheslav Krasylnyk
Dragons: 15 Carl Meyer, 14 Pat Howard, 13 Sam Beard, 12 Jack Dixon, 11 Adam Warren, 10 Angus O'Brien, 9 Charlie Davies, 8 Harrison Keddie 7 Nic Cudd, 6 James Thomas, 5 Rynard Landman, 4 Nick Crosswell, 3 Lloyd Fairbrother, 2 Rhys Buckley, 1 Phil Price
Replacements: 16 Darran Harris, 17 Tom Davies, 18 Craig Mitchell, 19 Matthew Screech, 20 Cory Hill, 21 Tavis Knoyle, 22 Rhys Jones, 23 Ashton Hewitt
Referee: Vlad Iordachescu (Romania)
Gloucester 37-8 Treviso
Gloucester made it 10 points out of 10 in Pool 1 of the Challenge Cup as they saw off the challenge of Treviso with relative ease.
The Cherry and Whites led 20-3 at the break and had two tries on the board from number eight Lewis Ludlow and wing Jonny May.
Michael Tagicakibau crossed seconds into the second-half to give Treviso a glimmer of hope but further tries from Matt Scott and replacement Callum Braley, the latter in the final minute, sealed the five-point win.
Tries: Ludlow, May, Scott, Braley
Cons: Laidlaw 3, Hook
Pens: Laidlaw 3
Gloucester: 15 James Hook, 14 Charlie Sharples, 13 Matt Scott, 12 Billy Twelvetrees, 11 Jonny May, 10 Billy Burns, 9 Greig Laidlaw, 8 Lewis Ludlow, 7 Matt Kvesic, 6 Ross Moriarty, 5 Joe Latta, 4 Tom Savage, 3 John Afoa, 2 Motu Matu'u, 1 Paddy McAllister
Replacements: 16 Richard Hibbard, 17 Cameron Orr, 18 Salesi Ma'afu, 19 Freddie Clarke, 20 Jacob Rowan, 21 Callum Braley, 22 Mark Atkinson, 23 Ollie Thorley
Treviso: 15 Jayden Hayward, 14 Michael Tagicakibau, 13 Tommaso Benvenuti, 12 Luke McLean, 11 Andrea Pratichetti, 10 Ian Mc Kinley, 9 Giorgio Bronzini, 1 Alberto de Marchi, 2 Ornel Gega, 3 Simone Ferrari, 4 Marco Fuser, 5 Dean Budd, 6 Francesco Minto, 7 Marco Lazzaroni, 8 Braam Steyn
Replacements:: 16 Luca Bigi, 17 Nicola Quaglio, 18 Tiziano Pasquali, 19 Filippo Gerosa, 20 Roberto Santamaria, 21 Tito Tebaldi, 22 Tommaso Iannone, 23 David Odiete
Referee: Dudley Phillips (Ireland)
Worcester Warriors 24-25 Brive
Worcester suffered a second defeat in as many Challenge Cup pool games on Saturday as they narrowly lost out to Brive at Sixways.
Brive were 10-7 up at the break thanks to a Taku Ngwenya try and the boot of Thomas Laranjeira, with a penalty try Worcester's offering.
Ben Te'o's crossing pushed the Warriors in front but scores from Said Hireche and replacement Thomas Acquier put Brive 25-17 ahead.
Consolation for Worcester came in the form of a bonus-point thanks to a late try from Andy Short but they're now off the pace in Pool 3.
Tries: Penalty Try, Te'o, Short
Cons: Heathcote, Shillcock 2
Tries: Ngwenya, Hireche, Acquier
Cons: Laranjeira, Bezy
Pens: Laranjeira, Bezy
Worcester Warriors: 15 Chris Pennell, 14 Andy Short, 13 Max Stelling, 12 Ben Te'o, 11 Josh Adams, 10 Tom Heathcote, 9 Luke Baldwin, 8 Matt Cox 7 Zac Xiourouppa, 6 Huw Taylor, 5 Christian Scotland-Williamson, 4 Andrew Kitchener, 3 Mike Daniels, 2 Matti Williams, 1 Ryan Bower
Replacements: 16 Jack Singleton, 17 Derrick Appiah, 18 Bi Alo, 19 Charlie Hewitt , 20 Sam Ripper Smith, 21 George DeCothi, 22 Jamie Shillcock, 23 Dean Hammond
Brive 15 Benjamin Lapeyre, 14 Taku Ngwenya, 13 Arnaud Mignardi, 12 Seremaia Burotu, 11 Guillaume Namy, 10 Thomas Laranjeira, 9 Vasil Lobzhanidze, 8 William Whetton, 7 Said Hireche, 6 Poutasi Luafutu, 5 Johan Snyman, 4 Jan Uys, 3 Soso Bekoshvili, 2 Guillaume Ribes, 1 Vivien Devisme
Replacements: 16 Thomas Acquier, 17 Damien Lavergne, 18 Kevin Buys, 19 Arnaud Mela, 20 Péniami Narisia, 21 David Delarue, 22 Nicolas Bézy, 23 Benito Masilevu
Referee: Gary Conway (Ireland)
Edinburgh 36-35 Harlequins
Edinburgh moved three points clear in Pool 5 of the Challenge Cup as they got the better of Harlequins in a thrilling contest at Murrayfield.
The Scots were flying at the break as tries from Allan Dell, Blair Kinghorn, Nasi Manu, Hamish Watson and Damian Hoyland put them 31-14 in front. Harlequins' first-half offerings were from Charlie Walker and via a penalty try.
Harlequins then managed to cut the margin in the second-half thanks to scores from Kyle Sinckler, another penalty try and one from Mat Luamanu as they edged in front at 31-35 to the good with just 13 minutes remaining.
But Edinburgh got over the finish line with their noses in front thanks to Tom Brown's 73rd minute try as they claimed a bonus-point win.
Tries: Dell, Kinghorn, Manu, Watson, Hoyland, Brown
Cons: Tovey 2, Kinghorn
Tries: Walker, Penalty Try 2, Sinckler, Luamanu
Cons: Evans 3, Swiel 2
Edinburgh: 15 Blair Kinghorn, 14 Damien Hoyland, 13 Chris Dean, 12 Phil Burleigh, 11 Tom Brown, 10 Jason Tovey, 9 Sean Kennedy, 8 Nasi Manu, 7 Hamish Watson, 6 Magnus Bradbury, 5 Grant Gilchrist, 4 Ben Toolis, 3 WP Nel, 2 Ross Ford, 1 Rory Sutherland
Replacements:: 16 Stuart McInally, 17 Allan Dell, 18 Felipe Arregui, 19 Fraser McKenzie, 20 Viliame Mata, 21 Sam Hidalgo-Clyne, 22 Michael Allen, 23 Glenn Bryce
Harlequins: 15 Mike Brown, 14 Marland Yarde, 13 Joe Marchant, 12 Jamie Roberts, 11 Charlie Walker, 10 Nick Evans, 9 Karl Dickson, 8 James Chisholm, 7 Luke Wallace, 6 Chris Robshaw, 5 James Horwill, 4 Sam Twomey, 3 Kyle Sinckler, 2 Rob Buchanan, 1 Joe Marler
Replacements: 16 Joe Gray, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Mat Luamanu, 21 Danny Care, 22 Tim Swiel, 23 Alofa Alofa
Referee: Romain Poite (France)
Lyon 13-31 Ospreys
Ospreys moved five points clear of Lyon after they won 31-13 in their Challenge Cup clash at Matmut Stadium with a try bonus-point.
A hat-trick from wing Keelan Giles saw him cross in the 15th, 30th and 46th minute before a late Sam Parry try brought up the maximum.
Ospreys were leading 17-3 at half-time and Lyon would only cross the whitewash in the 59th minute via Curtis Browning, with Franck Romanet's try in the 80th minute somewhat covering over what was a poor showing.
The other two teams in this pool, Newcastle Falcons and Grenoble, meet at Kingston Park on Sunday as they look for their first victory.
Tries: Browning, Romanet
Tries: Giles 3, Parry
Cons: Davies 4
Lyon: 15 Romain Loursac, 14 Franck Romanet, 13 Paul Bonnefond, 12 Thibaut Regard, 11 Henry Clunies-Ross, 10 Jacques Louis Potgieter, 9 Baptiste Couilloud, 8 Curtis Browning 7 Dylan Cretin, 6 Deon Fourie, 5 Maselino Paulino, 4 Felix Lambey, 3 David Attoub, 2 Ti'i Paulo, 1 Sami Mavinga
Replacements: 16 Vincent Giudicelli, 17 Tornike Mataradze, 18 BJ Botha, 19 Thibaut Privat, 20 Didier Tison, 21 Pierre-Louis Barassi, 22 Jerome Porical, 23 Nicolas Durand
Ospreys: 15 Daniel Evans, 14 Keelan Giles, 13 Jonathan Spratt, 12 Josh Matavesi, 11 Daf Howells, 10 Sam Davies, 9 Thomas Habberfield, 8 James King 7 Olly Cracknell, 6 Dan Lydiate, 5 Rory Thornton, 4 Lloyd Ashley, 3 Ma'afu Fia, 2 Scott Baldwin, 1 Nicky Smith
Replacements: 16 Sam Parry, 17 Paul James, 18 Rhodri Jones, 19 Adam Beard, 20 Rob McCusker, 21 Justin Tipuric, 22 Brendon Leonard, 23 Eli Walker
Referee: Andrew Brace (Ireland)