Lyon started their Challenge Cup campaign with an impressive bonus-point victory at Grenoble while Ospreys crushed Newcastle.
Friday's other two matches saw the Dragons overcome Brive at Rodney Parade and Cardiff Blues get the better of Bristol on the road.
Grenoble 13-39 Lyon
Lyon came from behind to pick up an impressive win at Grenoble that saw them score four tries at Stade des Alpes.
The hosts enjoyed a great start when hooker Loick Jammes scored with only a minute on the clock. With Gilles Bosch's extras it was 0-7.
Lyon hit back through their own hooker, Cameron Mapusua, in the 15th minute and with the boot of Jacques-Louis Potgieter keeping the tally ticking, the visitors were 13-10 in front by 29 minutes until Bosch levelled and then Potgieter struck again before the interval for 16-13.
Potgieter added to his personal haul with a further two penalties before the 47 minute mark which extended the gap to a healthy 22-13 cushion.
Centre Thibaut Regard crossed for Lyon to make it 27-13 on 67 minutes before flank Deon Fourie and wing Henry Clunies-Ross scored late on.
Pens: Bosch 2
Tries: Mapusua, Regard, Fourie, Clunies-Ross
Cons: Potgieter 2
Pens: Potgieter 5
Grenoble: 15 Bastien Guillemin, 14 Sisa Ledua Waqa, 13 Xavier Mignot, 12 Tino Nemani, 11 Edward Dratai Sawailau, 10 Gilles Bosch, 9 Lilian Saseras, 8 Fabien Alexandre, 7 Kevin Kornath, 6 Jonathan Best, 5 Mickael Capelli, 4 Ben Hand, 3 Walter Desmaison, 2 Loick Jammes, 1 Alexandre Dardet
Replacements: 16 Etienne Fourcade, 17 Dylan Jacquot, 18 Ali Oz, 19 Steven Giroud, 20 Loic Baradel, 21 Jeremy Valencot, 22 David Mele, 23 Pierre Mignot
Lyon: 15 Romain Loursac, 14 Franck Romanet, 13 Paul Bonnefond, 12 Thibaut Regard, 11 Henry Clunies-Ross, 10 Jacques Louis Potgieter, 9 Baptiste Couilloud, 8 Curtis Browning, 7 Dylan Cretin, 6 Deon Fourie, 5 Simon Christian Njewel, 4 Felix Lambey, 3 David Attoub, 2 Cameron Mapusua, 1 Sami Mavinga
Replacements: 16 Ti’i Paulo, 17 Tornike Mataradze, 18 Hamza Kaabèche, 19 Maselino Paulino, 20 Didier Tison, 21 Pierre-Louis Barassi, 22 Jerome Porical, 23 Augustin Figuerola
Referee: Dudley Philips (Ireland)
Ospreys 45-0 Newcastle
Ospreys made light work of Newcastle Falcons at the Liberty Stadium on Friday as they ran out comfortable seven-try winners.
They were three quarters of the way to a bonus-point by half-time as scores from Dan Biggar, Rhys Webb and Ashley Beck got them moving.
A second-string Falcons side were struggling to live with the PRO12 heavyweights, with their Welsh half-back pairing controlling the contest.
Further crossings from Scott Baldwin, Justin Tipuric and two from Keelan Giles wrapped up an impressive performance from the Welshmen.
Tries: Biggar, Webb, Beck, Baldwin, Tipuric, Giles 2
Cons: Biggar 5
Ospreys: 15 Daniel Evans, 14 Keelan Giles, 13 Ben John, 12 Ashley Beck, 11 Eli Walker, 10 Dan Biggar, 9 Rhys Webb, 8 Dan Baker, 7 Justin Tipuric, 6 Dan Lydiate, 5 Alun Wyn Jones, 4 Rory Thornton, 3 Ma’afu Fia, 2 Scott Baldwin, 1 Paul James
Replacements: 16 Sam Parry, 17 Gareth Thomas, 18 Rhodri Jones, 19 Lloyd Ashley, 20 James King, 21 Thomas Habberfield, 22 Sam Davies, 23 Josh Matavesi
Newcastle: 15 Brett Connon, 14 Marcus Watson, 13 Fred Burdon, 12 Craig Willis, 11 Belisario Agulla, 10 Joel Hodgson, 9 Micky Young, 8 Harrison Orr, 7 Dan Temm, 6 Glen Young, 5 Nick Civetta, 4 Will Witty, 3 David Wilson, 2 Ben Sowrey, 1 Alex Rogers
Replacements: 16 David Nelson, 17 Sam Lockwood, 18 Andy Foster, 19 Mouritz Botha, 20 Callum Chick, 21 Sam Egerton, 22 Juan Socino, 23 Alex Tait
Referee: David Wilkinson (Ireland)
Dragons 37-16 Brive
Dragons picked up only their second win of the season in all competitions as they defeated Brive with a bonus-point on Friday.
A first-half try from Rynard Landman and the boot of Nick Macleod saw them go in level at 13 apiece after Thomas Laranjeira had also crossed and kicked eight points for a Brive side that has been going well in the Top 14.
But after the break it was all the Dragons as Lewis Evans, Cory Hill, Hallam Amos and Adam Warren went over in a one-sided second-half.
Tries: Landman, Evans, Hill, Amos, Warren
Cons: Macleod, O'Brien 2
Pens: Laranjeira 3
Dragons: 15 Carl Meyer, 14 Ashton Hewitt, 13 Tyler Morgan, 12 Adam Warren, 11 Hallam Amos, 10 Nick MacLeod, 9 Charlie Davies, 8 Ed Jackson, 7 Lewis Evans, 6 James Thomas, 5 Rynard Landman, 4 Cory Hill, 3 Brok Harris, 2 Rhys Buckley, 1 Tom Davies
Replacements: 16 Darran Harris, 17 Phil Price, 18 Craig Mitchell, 19 Matthew Screech, 20 Harrison Keddie, 21 Sarel Pretorius, 22 Angus O’Brien, 23 Sam Beard
Brive: 15 Benjamin Lapeyre, 14 Elia Radikedike, 13 Arnaud Mignardi, 12 Christopher Tuatara, 11 Guillaume Namy, 10 Thomas Laranjeira, 9 Vasil Lobzhanidze, 8 Petrus Hauman, 7 Fabien Sanconnie, 6 William Whetton, 5 Johan Snyman, 4 Wilhelm Steenkamp, 3 Damien Jourdain, 2 Guillaume Ribes, 1 Vivien Devisme
Replacements: 16 Francois Da Ros, 17 Damien Lavergne, 18 Soso Bekoshvili, 19 Jan Uys, 20 Péniami Narisia, 21 Jean-Baptiste Pejoine, 22 Taku Ngwenya, 23 Sevanaia Galala
Referee: Craig Maxwell-Keys (England)
Bristol 20-33 Cardiff Blues
Cardiff Blues started their Challenge Cup pool campaign with a bonus-point win on the road as they saw off Bristol on Friday.
Tries from Rey Lee-Lo and Josh Turnbull set them on their way in the first-half as the visiting Blues went into the break leading 21-13.
Alex Cuthbert added their third crossing on 48 minutes before Tom James went over for the all-important fourth try with seven minutes to play as the Blues saw off Bristol, whose scorers were Max Crumpton and replacement Joe Joyce, his try coming in the final play of the game.
Tries: Crumpton, Joyce
Cons: Jarvis, Searle
Pens: Jarvis 2
For Cardiff Blues:
Tries: Lee-Lo, Turnbull, Cuthbert, James
Cons: Anscombe 2
Pens: Anscombe 3
Bristol: 15 Jack Wallace, 14 Tom Varndell, 13 Jack Tovey, 12 Thretton Palamo, 11 David Lemi, 10 Adrian Jarvis, 9 Rhodri Williams, 8 Mitch Eadie, 7 Olly Robinson, 6 Nick Koster, 5 Ben Glynn, 4 Ian Evans, 3 Gaston Cortes, 2 Max Crumpton, 1 Soane Tonga’uiha
Replacements: 16 Chris Brooker, 17 Jack O’Connell, 18 Jamal Ford-Robinson, 19 Joe Joyce, 20 Nick Fenton-Wells, 21 Andy Uren, 22 Billy Searle, 23 Luke Arscott
Cardiff Blues: 15 Matthew Morgan, 14 Alex Cuthbert, 13 Rey Lee-Lo, 12 Steven Shingler, 11 Tom James, 10 Gareth Anscombe, 9 Tomos Williams, 8 Nick Williams, 7 Ellis Jenkins (c), 6 Josh Turnbull, 5 Macauley Cook, 4 Jarrad Hoeata, 3 Scott Andrews, 2 Matthew Rees, 1 Rhys Gill
Replacements: 16 Kirby Myhill, 17 Gethin Jenkins, 18 Dillon Lewis, 19 James Down, 20 Cam Dolan, 21 Lloyd Williams, 22 Garyn Smith, 23 Dan Fish
Referee: Pascal Gauzère (France)