Bulls head coach Frans Ludeke has recalled props Morné Mellett and Trevor Nyakane to his starting line-up for their clash with the Crusaders at Loftus.
Both played off the bench in last weekend's win against the Force and replace Dean Greyling and Marcel van der Merwe in two of four changes to the pack.
In the other changes to the pack and team, Victor Matfield returns to the lock position, swapping places with Grant Hattingh, who moves back to the bench.
Lappies Labuschagne also did not recover from a chest injury sustained against the Force and will sit out. He will be replaced by Arno Botha, who moves up from the bench. Hanro Liebenberg takes over from Botha on the bench.
Ludeke highlighted the positives from the win over the Force, but also lauded the momentum the visitiors took from recent wins over the Lions and Cheetahs.
"We did a lot of things well against the Force, but our execution and defence were lacking. We failed to deliver the knock-out punch when they had 13 men on the field. It is a mindset as well, but few challenges are greater than beating the Crusaders, so I am pretty sure the guys will be up for it. It certainly showed in this week’s training," he said.
Captain Pierre Spies added: "We did some good things, but also played poorly at times and that nearly cost us the match. It is just not good enough at this level. We need to show we are the championship side we believe we are. Hopefully we will have the crowd support this week. This Crusaders team is a good one, but this is our turf and we need to defend it.
"We have lost twice at home and we cannot allow it to happen again. I think we have turned the corner and is keen to lead the guys onto the field."
Bulls: 15 Jesse Kriel, 14 Francois Hougaard, 13 JJ Engelbrecht, 12 Jan Serfontein, 11 Bjorn Basson, 10 Handré Pollard, 9 Rudy Paige, 8 Pierre Spies (c), 7 Arno Botha, 6 Deon Stegmann, 5 Victor Matfield, 4 Jacques du Plessis, 3 Trevor Nyakane, 2 Adriaan Strauss, 1 Morné Mellett.
Replacements: 16 Jaco Visagie, 17 Dean Greyling, 18 Marcel van der Merwe, 19 Grant Hattingh, 20 Hanro Liebenberg, 21 Piet van Zyl, 22 Tian Schoeman, 23 Jurgen Visser.
Date: Saturday, March 28
Kick-off: 19:10 local (17.10 GMT, 06.10 NZST, 04.10 AEST)
Venue: Loftus Versfeld, Pretoria
Referee: Angus Gardner (Australia)
Assistant referees: Marius van der Westhuizen (South Africa), Stephan Geldenhuys (South Africa)
Television match official: Deon van Blommestein (South Africa)