Argentina have made a total of nine changes, either in terms of position or personnel, to face South Africa this weekend.
Los Pumas recorded their first even win over South Africa at the 19th attempt last weekend in Durban.
Juan Martín Hernández moves from fly-half to inside centre with the return of Nicolás Sanchez at number ten, while Santiago Cordero and Matías Moroni come into the back-line along with Martín Landajo at scrum-half for Tomás Cubelli.
In the forwards Juan Manuel Leguizamón moves to number eight with the return of Juan Martín Fernández Lobbe at openside flanker with Tomás Lezana starting at six.
Benjamin Macome joins the surviving Tomás Lavanini in the second row while the front row is unchanged as Agustín Creevy leads the team once again.
Argentina: 15 Joaquín Tuculet, 14 Santiago Cordero, 13 Matías Moroni, 12 Juan Martín Hernández, 11 Juan Imhoff, 10 Nicolás Sánchez, 9 Martín Landajo, 8 Juan Manuel Legiuzamón, 7 Juan Martín Fernández Lobbe, 6 Tomás Lezana, 5 Tomás Lavanini, 4 Benjamin Macome, 3 Nahuel Tetaz Chaparro, 2 Agustín Creevy (c), 1 Marcos Ayerza
Replacements: 16 Julián Montoya, 17 Lucas Noguera, 18 Juan Pablo Orlandi, 19 Matias Alemanno, 20 Pablo Matera, 21 Tomás Cubelli, 22 Juan Pablo Socino, 23 Lucas González Amorosino
Date: Saturday, August 15
Venue: Vélez Sarsfield, Buenos Aires
Kick-off: 16:40 local (19:40 GMT, 21:40 SAST)
Referee: Glen Jackson (New Zealand)
Assistant Referees: Romain Poite (France), Mike Fraser (New Zealand)
TMO: George Ayoub (Australia)