Argentina head coach Daniel Hourcade has made three changes to his starting XV ahead of their meeting with Wales in Cardiff on Saturday.
Into the side comes wing Ramiro Moyano, inside centre Juan Martín Hernández and flanker Pablo Matera as they look to claim an away scalp.
Santiago Cordero drops down to the bench, as does Tomás Lezana, but there’s no spot in the matchday 23 for centre Jerónimo de la Fuente.
Argentina beat Japan 54-20 in Tokyo last week while Wales were overrun by Australia, who claimed a 32-8 win at the Principality Stadium.
Argentina: 15 Joaquín Tuculet, 14 Matías Moroni, 13 Matías Orlando, 12 Juan Martín Hernández, 11 Ramiro Moyano, 10 Nicolás Sánchez, 9 Martín Landajo, 8 Facundo Isa, 7 Javier Ortega Desio, 6 Pablo Matera, 5 Matías Alemanno, 4 Guido Petti, 3 Ramiro Herrera, 2 Agustín Creevy (c), 1 Lucas Noguera
Replacements: 16 Julián Montoya, 17 Santiago García Botta, 18 Enrique Pieretto, 19 Leonardo Senatore, 20 Tomás Lezana, 21 Tomás Cubelli, 22 Santiago Gonzalez Iglesias, 23 Santiago Cordero
Date: Saturday, November 12
Venue: Principality Stadium, Cardiff
Kick-off: 17:30 GMT
Referee: Angus Gardner (Australia)
Assistant Referees: Mike Fraser (New Zealand), Luke Pearce (England)
TMO: Shaun Davey (England)