Wallabies inside centre Pat McCabe and left winger Digby Ioane have been ruled out of any further participation in the 2013 B&I Lions tour due to injury.
Both players sustained injuries during Saturday's first Test of the series which will require further examination by specialists, ruling out any chance of their appearing further in the pivotal series.
McCabe re-injured his neck in a similar location to an injury first sustained on the end-of-year tour. He will see specialists in Sydney in the coming days to ascertain the way forward following scans.
Reds finisher Ioane suffered internal damage to his right shoulder and will also require further follow up scans, with surgery a possibility.
The pair will be joined on the sideline for the second Test by full-back Berrick Barnes, who was concussed in the first half of last week's match.
His recovery is being managed according to the IRB concussion guidelines and Barnes will not be considered for Saturday's second Test, although it is hoped he will have recovered in time to be considered for the third game.