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Ahead of a mouth-watering tussle between Italy and England in Rome, let us take a look over five battles that could prove crucial on Sunday.
Newcastle captain Will Welch hailed his team-mates following their impressive 26-14 Premiership win over Leicester at Kingston Park.
Stormers head coach Robbie Fleck was happy with his side’s solid performance in their 29-14 pre-season victory over the Jaguares.
Cardiff Blues head coach Danny Wilson has turned his side’s focus to their upcoming home games after they suffered a 13-7 loss to Treviso.
USA overcame Canada 30-22 in their Americas Rugby Championship match in Texas on Saturday, with Todd Clever scoring a hat-trick.
Sunwolves ran out 52-24 winners against a Top League XV in their only warm-up match prior to their maiden Super Rugby campaign.
Argentina’s Super Rugby franchise, the Jaguares, were defeated 29-14 by the Stormers at Newlands in their pre-season friendly.
Italy captain Sergio Parisse has called on England head coach Eddie Jones to respect his side ahead of their Sunday clash.
Wales got their Six Nations campaign on track with a win over Scotland but they were put under huge pressure by their opponents.
Ireland have been left counting their injured players after their 10-9 Six Nations loss to France in Paris on Saturday.